Yes that's right ... checking the valve clearances is the first thing anyone with a weird running problem should do BEFORE messing around with ANYTHING else ... I gave up on telling people to check and adjust their valve clearances in every post ... LOL ...
Carbs are pretty stable if they've been tuned right in the first place ... ie IF the engine was running great before with those settings ... then it suddenly starts running wonky ... it's unlikely to be the settings or jet sizes ... more likely a blockage somewhere ... or loss of valve adjustment ... or a failing ignition ...
Whenever you get a sudden problem (sputtering , coughing , dying , hard to start , stally) ... ask yourself if you rode thru' water or hosed the bike recently or changed where you got the fuel in the tank from ie ... scabbed fuel off a mate and poured it from his moms filthy old mower fuel can or used a dirty old funnel ... Stinged out on the cheapest crap from some crusty old gas station 'cause it was 2 cents a litre cheaper than your usual fuel ... Dropped the bike and bent something (in the case of tranny problems) ... IF you work backwards ... you can usually discover the answer to the cause of most problems ...
For ignition problems ... the quickest way to check and save a heap of effing around is to hook an inductive pickup power timing light to your plug lead ... then look into the light with the engine running at various revs ... if the light is missing even the slightest beat ANYWHERE ... you know 100% dead certain that the ignition is at fault ...