When you set up the carby and adjust the mixture,
Warm the bike up, then turn the idle speed screw in to raise the rev's another 800 rpm's or so
Now adjust the mixture screw in or out 1/4 turn at a time and let it settle for 10 second's
Listen the the way the engine is running, you want it running at the smoothest/fastest rev.
Once you think it's close then turn the idle speed screw back out till it's back to a normal idle speed.
Try the bike out after adjusting it.
That should be pretty close to spot on mixture's
Take note of what the bike is doing and at what throttle position if you need to adjust something.
EG, hesitate's off idle, stumble's at 1/4 throttle, feel's sluggish at wide open throttle
If after a ride and you want to adjust the mixture's a bit more, you may need to turn the mixture screw a tiny bit, only about 1/16 of a turn to adjust it from there
Is the carby one of these ?
If so it probably has a too small pilot jet. they come with a #15 but really like a #20 pilot jet