it depends on the compression ratio, octane of fuel, how rich or lean the air/fuel mixture is, how clean the airfilter is kept, and how its treated generally.
if your running a high compression engine, higher octane fuels are a must, some people have to run octane booster too.
if a bike is run too lean or without an airfilter, fuel will burn in the combustion chamber alot hotter than usual. this can cause excess wear on piston rings, scoring your bore, and creating hotspots. if you run too rich, you can get bore washing, where all the excess fuel will start to flood your oil, thinning it out, and making an unefficient burn, which will cause you to foul plugs, and not provide adequate enough lubrication to your engines bearings. if your airfiler is not cleaned often enough, alot of the dust that its supposed to catch will get into your engine, and those particles will once again cause wear on your bore and piston rings.