I've alway's just fixed puncture's
A mate used some tyre slime in his R1 when he was riding with mate's in france, he said at 110km/h he got a massive vibration in the front end and had to get it fixed a bit further down the road at a bike shop.
I've tried slime in the dune buggy but it couldn't keep up with the 3 corner jack's and Innocent weed spike's we used to get.
I pumped up the tyre and sprayed some water on it it one time and there were over 60 spot's bubbling on the one tyre, all 4 tyre's had about the same amount of puncture's
I ended up replacing all the tyre's with heavy duty one's in the end.
Depending on where you ride and how bad it is for puncture's, you could get the puncture proof tube's, but they are heavier too.